4QXH

Crystal structure of histone demethylase KDM2A-H3K36ME1 with NOG

Summary for 4QXH

• Entry DOI: 10.2210/pdb4qxh/pdb
• Related: 4qwn 4qx7 4qx8 4qxb 4qxc 4tn7
• Descriptor: Lysine-specific demethylase 2A, Histone H3.2, N-OXALYLGLYCINE, ... (6 entities in total)
• Functional Keywords: cupin subfamily fe(ii)/2-og dioxygenase, jmjc domain, histone demethylase, oxidoreductase-structural protein complex, oxidoreductase/structural protein
• Biological source: Mus musculus (mouse); More
• Cellular location: Nucleus: P84228
• Total number of polymer chains: 6
• Total formula weight: 96849.60

Authors

Cheng, Z.J.,Patel, D.J. (deposition date: 2014-07-20, release date: 2014-11-05)

• Primary citation: Cheng, Z.,Cheung, P.,Kuo, A.J.,Yukl, E.T.,Wilmot, C.M.,Gozani, O.,Patel, D.J.; A molecular threading mechanism underlies Jumonji lysine demethylase KDM2A regulation of methylated H3K36.; Genes Dev., 28:1758-1771, 2014; PubMed: 25128496; DOI: 10.1101/gad.246561.114

Experimental method

X-RAY DIFFRACTION (2.2 Å)