4QX8
Crystal structure of histone demethylase kdm2a-h3k36me3 complex with alpha-kg
Summary for 4QX8
Entry DOI | 10.2210/pdb4qx8/pdb |
Related | 2YU1 2YU2 4QWN 4QX7 4QXB 4QXC 4QXH 4TN7 |
Descriptor | Lysine-specific demethylase 2A, Histone H3.2, NICKEL (II) ION, ... (6 entities in total) |
Functional Keywords | cupin subfamily fe(ii)/2-og dioxygenase, jmjc domain, histone demethylase, oxidoreductase-structural protein complex, oxidoreductase/structural protein |
Biological source | Mus musculus (mouse) More |
Cellular location | Nucleus : F6YRW4 F6YRW4 P84228 |
Total number of polymer chains | 6 |
Total formula weight | 96905.75 |
Authors | Cheng, Z.J.,Patel, D.J. (deposition date: 2014-07-19, release date: 2014-11-05, Last modification date: 2018-01-24) |
Primary citation | Cheng, Z.,Cheung, P.,Kuo, A.J.,Yukl, E.T.,Wilmot, C.M.,Gozani, O.,Patel, D.J. A molecular threading mechanism underlies Jumonji lysine demethylase KDM2A regulation of methylated H3K36. Genes Dev., 28:1758-1771, 2014 Cited by PubMed: 25128496DOI: 10.1101/gad.246561.114 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.65 Å) |
Structure validation
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