4QV2

Unliganded crystal structure of Feline Norovirus P Domain co-crystallized with HBGA A-trisaccharide

4QV2 の概要

• エントリーDOI: 10.2210/pdb4qv2/pdb
• 関連するPDBエントリー: 4QUZ 4QVA
• 分子名称: VP1, 1,2-ETHANEDIOL (3 entities in total)
• 機能のキーワード: feline norovirus, capsid protein, p domain, protruding domain, viral protein
• 由来する生物種: Norovirus cat/GIV.2/CU081210E/USA/2010
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 73636.31

構造登録者

Singh, B.K.,Hansman, G.S. (登録日: 2014-07-14, 公開日: 2014-11-19, 最終更新日: 2024-03-20)

主引用文献

Singh, B.K.,Glatt, S.,Ferrer, J.L.,Koromyslova, A.D.,Leuthold, M.M.,Dunder, J.,Hansman, G.S.
Structural analysis of a feline norovirus protruding domain.
Virology, 474:181-185, 2015

PubMed Abstract: Norovirus infects different animals, including humans, mice, dogs, and cats. Here, we show an X-ray crystal structure of a feline GIV.2 norovirus capsid-protruding (P) domain to 2.35Å resolution. The feline GIV.2 P domain was reminiscent of human norovirus P domains, except for a novel P2 subdomain α-helix and an extended P1 subdomain interface loop. These new structural features likely obstructed histo-blood group antigens, which are attachment factors for human norovirus, from binding at the equivalent sites on the feline GIV.2 P domain. Additionally, an ELISA showed that the feline GIV.2 was antigenically distinct from a human GII.10 norovirus.

PubMed: 25463616
DOI: 10.1016/j.virol.2014.10.028

実験手法

X-RAY DIFFRACTION (1.68 Å)