4QV0
yCP beta5-A49T-A50V-double mutant
Summary for 4QV0
Entry DOI | 10.2210/pdb4qv0/pdb |
Related | 1RYP 4QTR 4QUX 4QV0 4QV1 4QV3 4QV4 4QV5 4QV6 4QV7 4QV8 4QV9 4QVL 4QVM 4QVN 4QVP 4QVQ |
Descriptor | Proteasome subunit alpha type-2, Proteasome subunit beta type-4, Proteasome subunit beta type-5, ... (17 entities in total) |
Functional Keywords | cancer, proteasome, bortezomib, drug resistance, binding analysis, hydrolase |
Biological source | Saccharomyces cerevisiae (Baker's yeast) More |
Total number of polymer chains | 28 |
Total formula weight | 731383.67 |
Authors | Huber, E.M.,Heinemeyer, W.,Groll, M. (deposition date: 2014-07-14, release date: 2015-02-04, Last modification date: 2023-09-20) |
Primary citation | Huber, E.M.,Heinemeyer, W.,Groll, M. Bortezomib-Resistant Mutant Proteasomes: Structural and Biochemical Evaluation with Carfilzomib and ONX 0914. Structure, 23:407-417, 2015 Cited by PubMed: 25599643DOI: 10.1016/j.str.2014.11.019 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.1 Å) |
Structure validation
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