4QUY

yCP beta5-A49S-mutant

Summary for 4QUY

Related4QTR 4QUY 4QV0 4QV1 4QV3 4QV4 4QV5 4QV6 4QV7 4QV8 4QV9 4QVL 4QVM 4QVN 4QVP 4QVQ 1RYP
DescriptorProteasome subunit alpha type-2, Proteasome subunit alpha type-3, Proteasome subunit alpha type-4, ... (17 entities in total)
Functional Keywordscancer, proteasome, bortezomib, drug resistance, binding analysis, hydrolase
Biological sourceSaccharomyces cerevisiae (Baker's yeast)
Cellular locationCytoplasm P23639 P23638 P40303 P32379 P40302 P21242 P21243 P25043 P25451 P22141 P30656 P23724 P30657 P38624
Total number of polymer chains28
Total molecular weight731348.12
Authors
Huber, E.M.,Heinemeyer, W.,Groll, M. (deposition date: 2014-07-14, release date: 2015-02-04, Last modification date: 2015-02-18)
Primary citation
Huber, E.M.,Heinemeyer, W.,Groll, M.
Bortezomib-Resistant Mutant Proteasomes: Structural and Biochemical Evaluation with Carfilzomib and ONX 0914.
Structure, 23:407-417, 2015
PubMed: 25599643 (PDB entries with the same primary citation)
DOI: 10.1016/j.str.2014.11.019
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.8 Å)
?

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.23310.3%3.2%1.5%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution