4QTD

Structure of human JNK1 in complex with SCH772984 and the AMPPNP-hydrolysed triphosphate revealing the second type-I binding mode

Summary for 4QTD

Entry DOI	10.2210/pdb4qtd/pdb
Related	4QTA 4QTB 4QTC 4QTE
Descriptor	Mitogen-activated protein kinase 8, 1,2-ETHANEDIOL, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ... (7 entities in total)
Functional Keywords	structural genomics, structural genomics consortium, sgc, transferase, kinase, mapk, signalling, inhibitor, allosteric, structural genomics consortium (sgc), transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Homo sapiens (human)
Cellular location	Cytoplasm: P45983
Total number of polymer chains	1
Total formula weight	44776.68
Authors	Chaikuad, A.,Keates, T.,von Delft, F.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Knapp, S.,Structural Genomics Consortium (SGC) (deposition date: 2014-07-07, release date: 2014-07-23, Last modification date: 2023-09-20)
Primary citation	Chaikuad, A.,M C Tacconi, E.,Zimmer, J.,Liang, Y.,Gray, N.S.,Tarsounas, M.,Knapp, S. A unique inhibitor binding site in ERK1/2 is associated with slow binding kinetics. Nat.Chem.Biol., 10:853-860, 2014 Cited by PubMed: 25195011 DOI: 10.1038/nchembio.1629 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.5 Å)

Structure validation