4QTB

Structure of human ERK1 in complex with SCH772984 revealing a novel inhibitor-induced binding pocket

Summary for 4QTB

• Entry DOI: 10.2210/pdb4qtb/pdb
• Related: 4QTA 4QTC 4QTD 4QTE
• Descriptor: Mitogen-activated protein kinase 3, 1,2-ETHANEDIOL, DIMETHYL SULFOXIDE, ... (7 entities in total)
• Functional Keywords: structural genomics, structural genomics consortium, sgc, transferase, kinase, mapk, signalling, inhibitor, allosteric, structural genomics consortium (sgc), transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Homo sapiens (human)
• Cellular location: Cytoplasm: P27361
• Total number of polymer chains: 2
• Total formula weight: 89504.72

Authors

Chaikuad, A.,Keates, T.,von Delft, F.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Knapp, S.,Structural Genomics Consortium (SGC) (deposition date: 2014-07-07, release date: 2014-07-23, Last modification date: 2023-09-20)

• Primary citation: Chaikuad, A.,M C Tacconi, E.,Zimmer, J.,Liang, Y.,Gray, N.S.,Tarsounas, M.,Knapp, S.; A unique inhibitor binding site in ERK1/2 is associated with slow binding kinetics.; Nat.Chem.Biol., 10:853-860, 2014; PubMed: 25195011; DOI: 10.1038/nchembio.1629

Experimental method

X-RAY DIFFRACTION (1.4 Å)