4QTD

Structure of human JNK1 in complex with SCH772984 and the AMPPNP-hydrolysed triphosphate revealing the second type-I binding mode

4QTD の概要

• エントリーDOI: 10.2210/pdb4qtd/pdb
• 関連するPDBエントリー: 4QTA 4QTB 4QTC 4QTE
• 分子名称: Mitogen-activated protein kinase 8, 1,2-ETHANEDIOL, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ... (7 entities in total)
• 機能のキーワード: structural genomics, structural genomics consortium, sgc, transferase, kinase, mapk, signalling, inhibitor, allosteric, structural genomics consortium (sgc), transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Cytoplasm: P45983
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 44776.68

構造登録者

Chaikuad, A.,Keates, T.,von Delft, F.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Knapp, S.,Structural Genomics Consortium (SGC) (登録日: 2014-07-07, 公開日: 2014-07-23, 最終更新日: 2023-09-20)

• 主引用文献: Chaikuad, A.,M C Tacconi, E.,Zimmer, J.,Liang, Y.,Gray, N.S.,Tarsounas, M.,Knapp, S.; A unique inhibitor binding site in ERK1/2 is associated with slow binding kinetics.; Nat.Chem.Biol., 10:853-860, 2014; PubMed: 25195011; DOI: 10.1038/nchembio.1629

実験手法

X-RAY DIFFRACTION (1.5 Å)