4QRE

Structure of Methionyl-tRNA Synthetase in complex with 1-(4-{4-[(1H-benzimidazol-2-ylmethyl)amino]-6-(4,5-dimethoxy-2-methylphenoxy)pyrimidin-2-yl}piperazin-1-yl)ethanone

4QRE の概要

• エントリーDOI: 10.2210/pdb4qre/pdb
• 関連するPDBエントリー: 4QRD
• 分子名称: Methionyl-tRNA synthetase, 1-(4-{4-[(1H-benzimidazol-2-ylmethyl)amino]-6-(4,5-dimethoxy-2-methylphenoxy)pyrimidin-2-yl}piperazin-1-yl)ethanone, ADENOSINE-5'-TRIPHOSPHATE, ... (5 entities in total)
• 機能のキーワード: protein synthesis, aminoacyl-trna synthetase, aminoacylation, cytosol, ligase-ligase inhibitor complex, ligase/ligase inhibitor
• 由来する生物種: Staphylococcus aureus
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 64190.61

構造登録者

Hilgers, M.T. (登録日: 2014-06-30, 公開日: 2015-07-29, 最終更新日: 2024-02-28)

• 主引用文献: Li, X.,Hilgers, M.T.,Stidham, M.,Brown-Driver, V.,Shaw, K.J.,Finn, J.; Discovery and SAR of a Novel Series of Pyrimidine Antibacterials Targeting Methionyl-tRNA Synthetase; to be published,

実験手法

X-RAY DIFFRACTION (1.7 Å)