4QRD

Structure of Methionyl-tRNA Synthetase in complex with N-(1H-benzimidazol-2-ylmethyl)-N'-(2,4-dichlorophenyl)-6-(morpholin-4-yl)-1,3,5-triazine-2,4-diamine

Summary for 4QRD

• Entry DOI: 10.2210/pdb4qrd/pdb
• Related: 4QRE
• Descriptor: Methionyl-tRNA synthetase, MAGNESIUM ION, N-(1H-benzimidazol-2-ylmethyl)-N'-(2,4-dichlorophenyl)-6-(morpholin-4-yl)-1,3,5-triazine-2,4-diamine, ... (4 entities in total)
• Functional Keywords: protein synthesis, aminoacyl-trna synthetase, aminoacylation, cytosol, ligase-ligase inhibitor complex, ligase/ligase inhibitor
• Biological source: Staphylococcus aureus
• Total number of polymer chains: 1
• Total formula weight: 63612.89

Authors

Li, X.,Hilgers, M.T.,Stidham, M.,Brown-Driver, V.,Shaw, K.J.,Finn, J. (deposition date: 2014-06-30, release date: 2015-07-29, Last modification date: 2024-02-28)

• Primary citation: Li, X.,Hilgers, M.T.,Stidham, M.,Brown-Driver, V.,Shaw, K.J.,Finn, J.; Discovery and SAR of a Novel Series of Pyrimidine Antibacterials Targeting Methionyl-tRNA Synthetase; to be published,

Experimental method

X-RAY DIFFRACTION (1.97 Å)