4QRE
Structure of Methionyl-tRNA Synthetase in complex with 1-(4-{4-[(1H-benzimidazol-2-ylmethyl)amino]-6-(4,5-dimethoxy-2-methylphenoxy)pyrimidin-2-yl}piperazin-1-yl)ethanone
Summary for 4QRE
Entry DOI | 10.2210/pdb4qre/pdb |
Related | 4QRD |
Descriptor | Methionyl-tRNA synthetase, 1-(4-{4-[(1H-benzimidazol-2-ylmethyl)amino]-6-(4,5-dimethoxy-2-methylphenoxy)pyrimidin-2-yl}piperazin-1-yl)ethanone, ADENOSINE-5'-TRIPHOSPHATE, ... (5 entities in total) |
Functional Keywords | protein synthesis, aminoacyl-trna synthetase, aminoacylation, cytosol, ligase-ligase inhibitor complex, ligase/ligase inhibitor |
Biological source | Staphylococcus aureus |
Total number of polymer chains | 1 |
Total formula weight | 64190.61 |
Authors | Hilgers, M.T. (deposition date: 2014-06-30, release date: 2015-07-29, Last modification date: 2024-02-28) |
Primary citation | Li, X.,Hilgers, M.T.,Stidham, M.,Brown-Driver, V.,Shaw, K.J.,Finn, J. Discovery and SAR of a Novel Series of Pyrimidine Antibacterials Targeting Methionyl-tRNA Synthetase to be published, |
Experimental method | X-RAY DIFFRACTION (1.7 Å) |
Structure validation
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