4QRD
Structure of Methionyl-tRNA Synthetase in complex with N-(1H-benzimidazol-2-ylmethyl)-N'-(2,4-dichlorophenyl)-6-(morpholin-4-yl)-1,3,5-triazine-2,4-diamine
Summary for 4QRD
Entry DOI | 10.2210/pdb4qrd/pdb |
Related | 4QRE |
Descriptor | Methionyl-tRNA synthetase, MAGNESIUM ION, N-(1H-benzimidazol-2-ylmethyl)-N'-(2,4-dichlorophenyl)-6-(morpholin-4-yl)-1,3,5-triazine-2,4-diamine, ... (4 entities in total) |
Functional Keywords | protein synthesis, aminoacyl-trna synthetase, aminoacylation, cytosol, ligase-ligase inhibitor complex, ligase/ligase inhibitor |
Biological source | Staphylococcus aureus |
Total number of polymer chains | 1 |
Total formula weight | 63612.89 |
Authors | Li, X.,Hilgers, M.T.,Stidham, M.,Brown-Driver, V.,Shaw, K.J.,Finn, J. (deposition date: 2014-06-30, release date: 2015-07-29, Last modification date: 2024-02-28) |
Primary citation | Li, X.,Hilgers, M.T.,Stidham, M.,Brown-Driver, V.,Shaw, K.J.,Finn, J. Discovery and SAR of a Novel Series of Pyrimidine Antibacterials Targeting Methionyl-tRNA Synthetase to be published, |
Experimental method | X-RAY DIFFRACTION (1.97 Å) |
Structure validation
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