4QQN
Protein arginine methyltransferase 3 in complex with compound MTV044246
Summary for 4QQN
Entry DOI | 10.2210/pdb4qqn/pdb |
Descriptor | PRMT3 protein, 1-{2-[1-(aminomethyl)cyclohexyl]ethyl}-3-isoquinolin-6-ylurea, GLYCEROL, ... (6 entities in total) |
Functional Keywords | prmt3, structural genomics, structural genomics consortium, sgc, transferase, epigenetics |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 1 |
Total formula weight | 38735.90 |
Authors | Dong, A.,Dobrovetsky, E.,Tempel, W.,He, H.,Zhao, K.,Smil, D.,Landon, M.,Luo, X.,Chen, Z.,Dai, M.,Yu, Z.,Lin, Y.,Zhang, H.,Zhao, K.,Schapira, M.,Brown, P.J.,Bountra, C.,Arrowsmith, C.H.,Edwards, A.M.,Vedadi, M.,Structural Genomics Consortium (SGC) (deposition date: 2014-06-27, release date: 2014-09-17, Last modification date: 2023-09-20) |
Primary citation | Kaniskan, H.U.,Eram, M.S.,Zhao, K.,Szewczyk, M.M.,Yang, X.,Schmidt, K.,Luo, X.,Xiao, S.,Dai, M.,He, F.,Zang, I.,Lin, Y.,Li, F.,Dobrovetsky, E.,Smil, D.,Min, S.J.,Lin-Jones, J.,Schapira, M.,Atadja, P.,Li, E.,Barsyte-Lovejoy, D.,Arrowsmith, C.H.,Brown, P.J.,Liu, F.,Yu, Z.,Vedadi, M.,Jin, J. Discovery of Potent and Selective Allosteric Inhibitors of Protein Arginine Methyltransferase 3 (PRMT3). J. Med. Chem., 61:1204-1217, 2018 Cited by PubMed: 29244490DOI: 10.1021/acs.jmedchem.7b01674 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.08 Å) |
Structure validation
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