4QQN

Protein arginine methyltransferase 3 in complex with compound MTV044246

4QQN の概要

• エントリーDOI: 10.2210/pdb4qqn/pdb
• 分子名称: PRMT3 protein, 1-{2-[1-(aminomethyl)cyclohexyl]ethyl}-3-isoquinolin-6-ylurea, GLYCEROL, ... (6 entities in total)
• 機能のキーワード: prmt3, structural genomics, structural genomics consortium, sgc, transferase, epigenetics
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 38735.90

構造登録者

Dong, A.,Dobrovetsky, E.,Tempel, W.,He, H.,Zhao, K.,Smil, D.,Landon, M.,Luo, X.,Chen, Z.,Dai, M.,Yu, Z.,Lin, Y.,Zhang, H.,Zhao, K.,Schapira, M.,Brown, P.J.,Bountra, C.,Arrowsmith, C.H.,Edwards, A.M.,Vedadi, M.,Structural Genomics Consortium (SGC) (登録日: 2014-06-27, 公開日: 2014-09-17, 最終更新日: 2023-09-20)

• 主引用文献: Kaniskan, H.U.,Eram, M.S.,Zhao, K.,Szewczyk, M.M.,Yang, X.,Schmidt, K.,Luo, X.,Xiao, S.,Dai, M.,He, F.,Zang, I.,Lin, Y.,Li, F.,Dobrovetsky, E.,Smil, D.,Min, S.J.,Lin-Jones, J.,Schapira, M.,Atadja, P.,Li, E.,Barsyte-Lovejoy, D.,Arrowsmith, C.H.,Brown, P.J.,Liu, F.,Yu, Z.,Vedadi, M.,Jin, J.; Discovery of Potent and Selective Allosteric Inhibitors of Protein Arginine Methyltransferase 3 (PRMT3).; J. Med. Chem., 61:1204-1217, 2018; PubMed: 29244490; DOI: 10.1021/acs.jmedchem.7b01674

実験手法

X-RAY DIFFRACTION (2.08 Å)