4QPF
New lower bone affinity bisphosphonate drug design for effective use in diseases characterized by abnormal bone resorption
Summary for 4QPF
Entry DOI | 10.2210/pdb4qpf/pdb |
Related | 1YQ7 1ZW5 2VF6 3B7L |
Descriptor | Farnesyl pyrophosphate synthase, [1-fluoro-2-(imidazo[1,2-a]pyridin-3-yl)ethane-1,1-diyl]bis(phosphonic acid), MAGNESIUM ION, ... (4 entities in total) |
Functional Keywords | isoprene biosynthesis, lipid synthesis, steroid biosynthesis, isoprenoid pathway, cholesterol synthesis, bisphosphonate, all-alpha helical prenyltransferase, isopentyl pyrophosphate, dimethylallyl pyrophosphate, transferase |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm: P14324 |
Total number of polymer chains | 1 |
Total formula weight | 43542.03 |
Authors | Ebetino, F.H.,Lundy, M.,Kwaasi, A.A.,Dunford, J.E.,Duan, Z.,Triffitt, J.,Mazur, A.,Jeans, G.,Barnett, B.L.,Russell, R.G.G. (deposition date: 2014-06-23, release date: 2015-06-24, Last modification date: 2023-09-20) |
Primary citation | Ebetino, F.H.,Lundy, M.,Kwaasi, A.A.,Dunford, J.E.,Duan, Z.,Triffitt, J.,Mazur, A.,Jeans, G.,Barnett, B.L.,Russell, R.G.G. New lower bone affinity bisphosphonate drug design for effective use in diseases characterized by abnormal bone resorption To be Published, |
Experimental method | X-RAY DIFFRACTION (1.59 Å) |
Structure validation
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