4QPF

New lower bone affinity bisphosphonate drug design for effective use in diseases characterized by abnormal bone resorption

Summary for 4QPF

• Entry DOI: 10.2210/pdb4qpf/pdb
• Related: 1YQ7 1ZW5 2VF6 3B7L
• Descriptor: Farnesyl pyrophosphate synthase, [1-fluoro-2-(imidazo[1,2-a]pyridin-3-yl)ethane-1,1-diyl]bis(phosphonic acid), MAGNESIUM ION, ... (4 entities in total)
• Functional Keywords: isoprene biosynthesis, lipid synthesis, steroid biosynthesis, isoprenoid pathway, cholesterol synthesis, bisphosphonate, all-alpha helical prenyltransferase, isopentyl pyrophosphate, dimethylallyl pyrophosphate, transferase
• Biological source: Homo sapiens (human)
• Cellular location: Cytoplasm: P14324
• Total number of polymer chains: 1
• Total formula weight: 43542.03

Authors

Ebetino, F.H.,Lundy, M.,Kwaasi, A.A.,Dunford, J.E.,Duan, Z.,Triffitt, J.,Mazur, A.,Jeans, G.,Barnett, B.L.,Russell, R.G.G. (deposition date: 2014-06-23, release date: 2015-06-24, Last modification date: 2023-09-20)

• Primary citation: Ebetino, F.H.,Lundy, M.,Kwaasi, A.A.,Dunford, J.E.,Duan, Z.,Triffitt, J.,Mazur, A.,Jeans, G.,Barnett, B.L.,Russell, R.G.G.; New lower bone affinity bisphosphonate drug design for effective use in diseases characterized by abnormal bone resorption; To be Published,

Experimental method

X-RAY DIFFRACTION (1.59 Å)