4QPF

New lower bone affinity bisphosphonate drug design for effective use in diseases characterized by abnormal bone resorption

4QPF の概要

• エントリーDOI: 10.2210/pdb4qpf/pdb
• 関連するPDBエントリー: 1YQ7 1ZW5 2VF6 3B7L
• 分子名称: Farnesyl pyrophosphate synthase, [1-fluoro-2-(imidazo[1,2-a]pyridin-3-yl)ethane-1,1-diyl]bis(phosphonic acid), MAGNESIUM ION, ... (4 entities in total)
• 機能のキーワード: isoprene biosynthesis, lipid synthesis, steroid biosynthesis, isoprenoid pathway, cholesterol synthesis, bisphosphonate, all-alpha helical prenyltransferase, isopentyl pyrophosphate, dimethylallyl pyrophosphate, transferase
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Cytoplasm: P14324
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 43542.03

構造登録者

Ebetino, F.H.,Lundy, M.,Kwaasi, A.A.,Dunford, J.E.,Duan, Z.,Triffitt, J.,Mazur, A.,Jeans, G.,Barnett, B.L.,Russell, R.G.G. (登録日: 2014-06-23, 公開日: 2015-06-24, 最終更新日: 2023-09-20)

• 主引用文献: Ebetino, F.H.,Lundy, M.,Kwaasi, A.A.,Dunford, J.E.,Duan, Z.,Triffitt, J.,Mazur, A.,Jeans, G.,Barnett, B.L.,Russell, R.G.G.; New lower bone affinity bisphosphonate drug design for effective use in diseases characterized by abnormal bone resorption; To be Published,

実験手法

X-RAY DIFFRACTION (1.59 Å)