4QNQ

Crystal Structure Analysis of full-length Bcl-XL in complex with the inhibitor ABT-263

Summary for 4QNQ

• Entry DOI: 10.2210/pdb4qnq/pdb
• Descriptor: Bcl-2-like protein 1, 4-(4-{[2-(4-chlorophenyl)-5,5-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-[(4-{[(2R)-4-(morpholin-4-yl)-1-(phenylsulfanyl)butan-2-yl]amino}-3-[(trifluoromethyl)sulfonyl]phenyl)sulfonyl]benzamide (3 entities in total)
• Functional Keywords: alpha-helical protein, apoptosis, apoptosis-apoptosis inhibitor complex, apoptosis/apoptosis inhibitor
• Biological source: Rattus norvegicus (rat)
• Cellular location: Isoform Bcl-X(L): Mitochondrion inner membrane: P53563
• Total number of polymer chains: 12
• Total formula weight: 333951.32

Authors

Korste, A.,Vetter, I.R.,Stoll, R. (deposition date: 2014-06-18, release date: 2015-10-28, Last modification date: 2023-09-20)

• Primary citation: Korste, A.,Vetter, I.R.,Stoll, R.; Crystal Structure Analysis of full-length Bcl-XL in complex with the inhibitor ABT-263; TO BE PUBLISHED,

Experimental method

X-RAY DIFFRACTION (2.3 Å)