4QMD

Crystal structure of human envoplakin plakin repeat domain

Summary for 4QMD

Entry DOI	10.2210/pdb4qmd/pdb
Descriptor	Envoplakin (2 entities in total)
Functional Keywords	envoplakin, periplakin, plakin protein, plakin repeat domain, cornified envelope, epidermal permeability barrier, keratinocyte, terminal differentiation, intermediate filament, vimentin, cytoskeleton, cell junction, desmosome, paraneoplastic pemphigus, cell adhesion
Biological source	Homo sapiens (human)
Cellular location	Cell junction, desmosome: Q92817
Total number of polymer chains	2
Total formula weight	42480.75
Authors	Mohammed, F.,Al-Jassar, C.,White, S.A.,Fogl, C.,Jeeves, M.,Knowles, T.J.,Odinstova, E.,Rodriguez-Zamora, P.,Overduin, M.,Chidgey, M. (deposition date: 2014-06-16, release date: 2015-07-29, Last modification date: 2024-02-28)
Primary citation	Fogl, C.,Mohammed, F.,Al-Jassar, C.,Jeeves, M.,Knowles, T.J.,Rodriguez-Zamora, P.,White, S.A.,Odintsova, E.,Overduin, M.,Chidgey, M. Mechanism of intermediate filament recognition by plakin repeat domains revealed by envoplakin targeting of vimentin. Nat Commun, 7:10827-10827, 2016 Cited by PubMed: 26935805 DOI: 10.1038/ncomms10827 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.601 Å)

Structure validation