4QMD

Crystal structure of human envoplakin plakin repeat domain

4QMD の概要

• エントリーDOI: 10.2210/pdb4qmd/pdb
• 分子名称: Envoplakin (2 entities in total)
• 機能のキーワード: envoplakin, periplakin, plakin protein, plakin repeat domain, cornified envelope, epidermal permeability barrier, keratinocyte, terminal differentiation, intermediate filament, vimentin, cytoskeleton, cell junction, desmosome, paraneoplastic pemphigus, cell adhesion
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Cell junction, desmosome: Q92817
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 42480.75

構造登録者

Mohammed, F.,Al-Jassar, C.,White, S.A.,Fogl, C.,Jeeves, M.,Knowles, T.J.,Odinstova, E.,Rodriguez-Zamora, P.,Overduin, M.,Chidgey, M. (登録日: 2014-06-16, 公開日: 2015-07-29, 最終更新日: 2024-02-28)

• 主引用文献: Fogl, C.,Mohammed, F.,Al-Jassar, C.,Jeeves, M.,Knowles, T.J.,Rodriguez-Zamora, P.,White, S.A.,Odintsova, E.,Overduin, M.,Chidgey, M.; Mechanism of intermediate filament recognition by plakin repeat domains revealed by envoplakin targeting of vimentin.; Nat Commun, 7:10827-10827, 2016; PubMed: 26935805; DOI: 10.1038/ncomms10827

実験手法

X-RAY DIFFRACTION (1.601 Å)