4QJR

Crystal structure of human nuclear receptor sf-1 (nr5a1) bound to its hormone pip3 at 2.4 a resolution

4QJR の概要

• エントリーDOI: 10.2210/pdb4qjr/pdb
• 分子名称: Steroidogenic factor 1, Peroxisome proliferator-activated receptor gamma coactivator 1-alpha, (2S)-3-{[(R)-{[(1S,2S,3R,4S,5S,6S)-2,6-dihydroxy-3,4,5-tris(phosphonooxy)cyclohexyl]oxy}(hydroxy)phosphoryl]oxy}propane -1,2-diyl dihexadecanoate, ... (5 entities in total)
• 機能のキーワード: nuclear hormone receptor, nr5a1, sf-1 ligand bindingnuclear domain, regulatory ligands, transcription, transcription regulation, structural genomics, joint center for structural genomics, jcsg, protein structure initiative, psi-biology, partnership for stem cell biology, pip3, pip2, nucleus, nuclear phosphatidylinositol phosphates, transcription factor-hormone complex, stemcell, transcription factor/hormone
• 由来する生物種: Homo sapiens (human); 詳細
• 細胞内の位置: Nucleus : Q13285; Isoform 1: Nucleus. Isoform B4: Nucleus. Isoform B4-8a: Cytoplasm. Isoform B5: Nucleus. Isoform 9: Nucleus : Q9UBK2
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 30596.32

構造登録者

Joint Center for Structural Genomics (JCSG),Partnership for Stem Cell Biology (STEMCELL) (登録日: 2014-06-04, 公開日: 2014-07-30, 最終更新日: 2024-03-13)

• 主引用文献: Blind, R.D.,Sablin, E.P.,Kuchenbecker, K.M.,Chiu, H.J.,Deacon, A.M.,Das, D.,Fletterick, R.J.,Ingraham, H.A.; The signaling phospholipid PIP3 creates a new interaction surface on the nuclear receptor SF-1.; Proc.Natl.Acad.Sci.USA, 111:15054-15059, 2014; PubMed: 25288771; DOI: 10.1073/pnas.1416740111

実験手法

X-RAY DIFFRACTION (2.4 Å)