4QJ1

Co-crystal structure of the catalytic domain of the inosine monophosphate dehydrogenase from Cryptosporidium parvum with inhibitor N109

Summary for 4QJ1

• Entry DOI: 10.2210/pdb4qj1/pdb
• Related: 3FFS 4IXH
• Descriptor: Inosine-5'-monophosphate dehydrogenase, INOSINIC ACID, N-(4-chloro-3-methoxyphenyl)-2-(4-oxochromeno[4,3-c]pyrazol-1(4H)-yl)acetamide, ... (7 entities in total)
• Functional Keywords: structural genomics, niaid, national institute of allergy and infectious diseases, center for structural genomics of infectious diseases, csgid, alpha-beta fold, tim barrel, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor
• Biological source: Cryptosporidium parvum; More
• Cellular location: Cytoplasm : Q8T6T2
• Total number of polymer chains: 4
• Total formula weight: 157245.95

Authors

Kim, Y.,Makowska-Grzyska, M.,Gu, M.,Hedstrom, L.,Anderson, W.F.,Joachimiak, A.,Center for Structural Genomics of Infectious Diseases (CSGID) (deposition date: 2014-06-03, release date: 2014-08-06, Last modification date: 2023-09-20)

• Primary citation: Kim, Y.,Makowska-Grzyska, M.,Gu, M.,Hedstrom, L.,Anderson, W.F.,Joachimiak, A.; Co-crystal structure of the catalytic domain of the inosine monophosphate dehydrogenase from Cryptosporidium parvum with inhibitor N109; To be Published,

Experimental method

X-RAY DIFFRACTION (2.415 Å)