4QHP

Crystal structure of Aminopeptidase N in complex with the phosphinic dipeptide analogue LL-(R,S)-hPheP[CH2]Phe(4-CH2NH2)

4QHP の概要

• エントリーDOI: 10.2210/pdb4qhp/pdb
• 分子名称: Aminopeptidase N, (2S)-2-[4-(aminomethyl)benzyl]-3-[(R)-[(1R)-1-amino-3-phenylpropyl](hydroxy)phosphoryl]propanoic acid, (2R)-2-[4-(aminomethyl)benzyl]-3-[(R)-[(1R)-1-amino-3-phenylpropyl](hydroxy)phosphoryl]propanoic acid, ... (8 entities in total)
• 機能のキーワード: zn-dependent, apn, (s)-2-[4-(aminomethyl)benzyl]-3-[(r)-1-amino-3-phenylpropyl(hydroxy)phosphoryl]propanoic acid, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Neisseria meningitidis
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 101206.96

構造登録者

Nocek, B.,Joachimiak, A. (登録日: 2014-05-28, 公開日: 2014-09-24, 最終更新日: 2023-12-06)

• 主引用文献: Vassiliou, S.,Weglarz-Tomczak, E.,Berlicki, L.,Paweczak, M.,Nocek, B.,Mulligan, R.,Joachimiak, A.,Mucha, A.; Structure-guided, single-point modifications in the phosphinic dipeptide structure yield highly potent and selective inhibitors of neutral aminopeptidases.; J.Med.Chem., 57:8140-8151, 2014; PubMed: 25192493; DOI: 10.1021/jm501071f

実験手法

X-RAY DIFFRACTION (1.6 Å)