4QH3

X-ray structure of the adduct formed between bovine pancreatic ribonuclease and trans-dimethylamine methylamine dichlorido platinum(II)

4QH3 の概要

• エントリーDOI: 10.2210/pdb4qh3/pdb
• 関連するPDBエントリー: 4QGZ
• 分子名称: Ribonuclease pancreatic, bis(chloranyl)-(dimethylamino)-(methylamino)platinum (3 entities in total)
• 機能のキーワード: hydrolase, rna binding
• 由来する生物種: Bos taurus (bovine,cow,domestic cattle,domestic cow)
• 細胞内の位置: Secreted: P61823
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 30137.52

構造登録者

Russo Krauss, I.,Merlino, A. (登録日: 2014-05-26, 公開日: 2014-07-30, 最終更新日: 2014-08-20)

• 主引用文献: Messori, L.,Marzo, T.,Michelucci, E.,Russo Krauss, I.,Navarro-Ranninger, C.,Quiroga, A.G.,Merlino, A.; Interactions between Anticancer trans-Platinum Compounds and Proteins: Crystal Structures and ESI-MS Spectra of Two Protein Adducts of trans-(Dimethylamino)(methylamino)dichloridoplatinum(II).; Inorg.Chem., 53:7806-7808, 2014; PubMed: 25025479; DOI: 10.1021/ic5012583

実験手法

X-RAY DIFFRACTION (2 Å)