4QGE
phosphodiesterase-9A in complex with inhibitor WYQ-C36D
Summary for 4QGE
| Entry DOI | 10.2210/pdb4qge/pdb |
| Descriptor | Phosphodiesterase 9A, N~2~-(1-cyclopentyl-4-oxo-4,7-dihydro-1H-pyrazolo[3,4-d]pyrimidin-6-yl)-N-(4-methoxyphenyl)-D-alaninamide, ZINC ION, ... (5 entities in total) |
| Functional Keywords | pde9 catalytic domain, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
| Biological source | Pan troglodytes (Chimpanzee) |
| Total number of polymer chains | 2 |
| Total formula weight | 124550.47 |
| Authors | Shao, Y.-X.,Huang, M.,Cui, W.,Ke, H. (deposition date: 2014-05-22, release date: 2014-12-10, Last modification date: 2024-04-03) |
| Primary citation | Shao, Y.X.,Huang, M.,Cui, W.,Feng, L.J.,Wu, Y.,Cai, Y.,Li, Z.,Zhu, X.,Liu, P.,Wan, Y.,Ke, H.,Luo, H.B. Discovery of a Phosphodiesterase 9A Inhibitor as a Potential Hypoglycemic Agent. J.Med.Chem., 57:10304-10313, 2014 Cited by PubMed: 25432025DOI: 10.1021/jm500836h PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
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