4QD2

Molecular basis for disruption of E-cadherin adhesion by botulinum neurotoxin A complex

Summary for 4QD2

• Entry DOI: 10.2210/pdb4qd2/pdb
• Descriptor: Hemagglutinin component HA33, Hemagglutinin component HA17, Hemagglutinin component HA70, ... (6 entities in total)
• Functional Keywords: oral toxicity, botulinum neurotoxin, e-cadherin, ha70, ha17, ha33, cell adhesion
• Biological source: Clostridium botulinum; More
• Cellular location: Cell junction: P09803
• Total number of polymer chains: 10
• Total formula weight: 274921.05

Authors

Lee, K.,Zhong, X.,Gu, S.,Kruel, A.,Dorner, M.B.,Perry, K.,Rummel, A.,Dong, M.,Jin, R. (deposition date: 2014-05-13, release date: 2014-06-25, Last modification date: 2023-09-20)

• Primary citation: Lee, K.,Zhong, X.,Gu, S.,Kruel, A.M.,Dorner, M.B.,Perry, K.,Rummel, A.,Dong, M.,Jin, R.; Molecular basis for disruption of E-cadherin adhesion by botulinum neurotoxin A complex.; Science, 344:1405-1410, 2014; PubMed: 24948737; DOI: 10.1126/science.1253823

Experimental method

X-RAY DIFFRACTION (2.4 Å)