4QBZ
Crystal structure of human TLR8 in complex with DS-802
Summary for 4QBZ
Entry DOI | 10.2210/pdb4qbz/pdb |
Related | 4QC0 |
Descriptor | Toll-like receptor 8, alpha-D-mannopyranose-(2-3)-[beta-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (8 entities in total) |
Functional Keywords | leucine rich repeat, glycosylation, innate immunity, rna recognition, ssrna, rna binding, secreted, structure-based ligand design, tlr8 and tlr7 agonist, vaccine adjuvants, rna receptor, antiviral and antitumor drug binding, rna binding protein |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 2 |
Total formula weight | 192267.99 |
Authors | Tanji, H.,Ohto, U.,Shimizu, T. (deposition date: 2014-05-09, release date: 2014-10-22, Last modification date: 2020-07-29) |
Primary citation | Yoo, E.,Salunke, D.B.,Sil, D.,Guo, X.,Salyer, A.C.D.,Hermanson, A.R.,Kumar, M.,Malladi, S.S.,Balakrishna, R.,Thompson, W.H.,Tanji, H.,Ohto, U.,Shimizu, T.,David, S.A. Determinants of Activity at Human Toll-like Receptors 7 and 8: Quantitative Structure-Activity Relationship (QSAR) of Diverse Heterocyclic Scaffolds J.Med.Chem., 57:7955-7970, 2014 Cited by PubMed: 25192394DOI: 10.1021/jm500744f PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
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