4QBZ

Crystal structure of human TLR8 in complex with DS-802

4QBZ の概要

• エントリーDOI: 10.2210/pdb4qbz/pdb
• 関連するPDBエントリー: 4QC0
• 分子名称: Toll-like receptor 8, alpha-D-mannopyranose-(2-3)-[beta-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (8 entities in total)
• 機能のキーワード: leucine rich repeat, glycosylation, innate immunity, rna recognition, ssrna, rna binding, secreted, structure-based ligand design, tlr8 and tlr7 agonist, vaccine adjuvants, rna receptor, antiviral and antitumor drug binding, rna binding protein
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 192267.99

構造登録者

Tanji, H.,Ohto, U.,Shimizu, T. (登録日: 2014-05-09, 公開日: 2014-10-22, 最終更新日: 2020-07-29)

• 主引用文献: Yoo, E.,Salunke, D.B.,Sil, D.,Guo, X.,Salyer, A.C.D.,Hermanson, A.R.,Kumar, M.,Malladi, S.S.,Balakrishna, R.,Thompson, W.H.,Tanji, H.,Ohto, U.,Shimizu, T.,David, S.A.; Determinants of Activity at Human Toll-like Receptors 7 and 8: Quantitative Structure-Activity Relationship (QSAR) of Diverse Heterocyclic Scaffolds; J.Med.Chem., 57:7955-7970, 2014; PubMed: 25192394; DOI: 10.1021/jm500744f

実験手法

X-RAY DIFFRACTION (2 Å)