4QBB
Structure of the foot-and-mouth disease virus leader proteinase in complex with inhibitor (N~2~-[(3S)-4-({(2R)-1-[(4-CARBAMIMIDAMIDOBUTYL)AMINO]-4-METHYL-1-OXOPENTAN-2-YL}AMINO)-3-HYDROXY-4-OXOBUTANOYL]-L-ARGINYL-L-PROLINAMIDE)
4QBB の概要
エントリーDOI | 10.2210/pdb4qbb/pdb |
関連するPDBエントリー | 1QMY |
分子名称 | Leader protease, POTASSIUM ION, N~2~-[(3S)-4-({(2R)-1-[(4-carbamimidamidobutyl)amino]-4-methyl-1-oxopentan-2-yl}amino)-3-hydroxy-4-oxobutanoyl]-L-arginyl-L-prolinamide, ... (5 entities in total) |
機能のキーワード | papain-like cysteine proteinase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
由来する生物種 | Foot-and-mouth disease virus (FMDV) |
細胞内の位置 | Protein VP2: Virion. Protein VP3: Virion. Protein VP1: Virion. Protein 2B: Host cytoplasmic vesicle membrane ; Peripheral membrane protein ; Cytoplasmic side . Protein 2C: Host cytoplasmic vesicle membrane ; Peripheral membrane protein ; Cytoplasmic side . Protein 3A: Host cytoplasmic vesicle membrane ; Peripheral membrane protein ; Cytoplasmic side . Protein 3B-1: Virion . Protein 3B-2: Virion . Protein 3B-3: Virion . Picornain 3C: Host cytoplasm . RNA-directed RNA polymerase 3D-POL: Host cytoplasmic vesicle membrane ; Peripheral membrane protein ; Cytoplasmic side : P03305 |
タンパク質・核酸の鎖数 | 3 |
化学式量合計 | 59135.22 |
構造登録者 | Grishkovskaya, I.,Steinberger, J.,Cencic, R.,Juliano, M.A.,Juliano, L.,Skern, T. (登録日: 2014-05-07, 公開日: 2014-11-05) |
主引用文献 | Steinberger, J.,Grishkovskaya, I.,Cencic, R.,Juliano, L.,Juliano, M.A.,Skern, T. Foot-and-mouth disease virus leader proteinase: Structural insights into the mechanism of intermolecular cleavage. Virology, 468-470C:397-408, 2014 Cited by PubMed: 25240326DOI: 10.1016/j.virol.2014.08.023 主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (1.6 Å) |
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