4QAP
The second sphere residue T263 is important for function and activity of PTP1B through modulating WPD loop
Summary for 4QAP
Entry DOI | 10.2210/pdb4qap/pdb |
Related | 4QAH 4QBE 4QBW |
Descriptor | Tyrosine-protein phosphatase non-receptor type 1, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL (3 entities in total) |
Functional Keywords | tyrosine phosphorylation, hydrolase |
Biological source | Homo sapiens (human) |
Cellular location | Endoplasmic reticulum membrane ; Peripheral membrane protein ; Cytoplasmic side : P18031 |
Total number of polymer chains | 1 |
Total formula weight | 34968.87 |
Authors | |
Primary citation | Xiao, P.,Wang, X.,Wang, H.M.,Fu, X.L.,Cui, F.A.,Yu, X.,Wen, S.S.,Bi, W.X.,Sun, J.P. The second-sphere residue T263 is important for the function and catalytic activity of PTP1B via interaction with the WPD-loop Int.J.Biochem.Cell Biol., 57:84-95, 2014 Cited by PubMed: 25450460DOI: 10.1016/j.biocel.2014.10.004 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.903 Å) |
Structure validation
Download full validation report