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4QAH

The second sphere residue T263 is important for function and activity of PTP1B through modulating WPD loop

Summary for 4QAH
Entry DOI10.2210/pdb4qah/pdb
Related4QAP 4QBE 4QBW
DescriptorTyrosine-protein phosphatase non-receptor type 1, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL (3 entities in total)
Functional Keywordstyrosine phosphorylation, hydrolase
Biological sourceHomo sapiens (human)
Cellular locationEndoplasmic reticulum membrane ; Peripheral membrane protein ; Cytoplasmic side : P18031
Total number of polymer chains1
Total formula weight34983.94
Authors
Xiao, P.,Wang, X.,Wang, H.M.,Fu, X.L.,Cui, F.A.,Bi, W.X. (deposition date: 2014-05-05, release date: 2014-12-24, Last modification date: 2024-03-20)
Primary citationXiao, P.,Wang, X.,Wang, H.M.,Fu, X.L.,Cui, F.A.,Yu, X.,Wen, S.S.,Bi, W.X.,Sun, J.P.
The second-sphere residue T263 is important for the function and catalytic activity of PTP1B via interaction with the WPD-loop
Int.J.Biochem.Cell Biol., 57C:84-95, 2014
Cited by
PubMed: 25450460
DOI: 10.1016/j.biocel.2014.10.004
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.403 Å)
Structure validation

217705

数据于2024-03-27公开中

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