4QAG

Structure of a dihydroxycoumarin active-site inhibitor in complex with the RNASE H domain of HIV-1 reverse transcriptase

「4JE2」から置き換えられました

4QAG の概要

• エントリーDOI: 10.2210/pdb4qag/pdb
• 関連するPDBエントリー: 3IFJ 3IG1 3K2P 3QLH 4G1Q
• 分子名称: Reverse transcriptase/ribonuclease H, MANGANESE (II) ION, (7,8-dihydroxy-2-oxo-2H-chromen-4-yl)acetic acid, ... (4 entities in total)
• 機能のキーワード: rnase h inhibitor, structure-based drug design, active site, transferase, dihydroxycoumarin analogs, dihydroxy-benzopyrone derivatives, divalent cation chelator, aids, reverse transcriptase, protein-inhibitor complex, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Human immunodeficiency virus type 1 (HIV-1)
• 細胞内の位置: Matrix protein p17: Virion (Potential). Capsid protein p24: Virion (Potential). Nucleocapsid protein p7: Virion (Potential). Reverse transcriptase/ribonuclease H: Virion (Potential). Integrase: Virion (Potential): P03366
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 30121.44

構造登録者

Himmel, D.M.,Ho, W.C.,Arnold, E. (登録日: 2014-05-04, 公開日: 2014-06-04, 最終更新日: 2023-09-20)

• 主引用文献: Himmel, D.M.,Myshakina, N.S.,Ilina, T.,Van Ry, A.,Ho, W.C.,Parniak, M.A.,Arnold, E.; Structure of a Dihydroxycoumarin Active-Site Inhibitor in Complex with the RNase H Domain of HIV-1 Reverse Transcriptase and Structure-Activity Analysis of Inhibitor Analogs.; J.Mol.Biol., 426:2617-2631, 2014; PubMed: 24840303; DOI: 10.1016/j.jmb.2014.05.006

実験手法

X-RAY DIFFRACTION (1.712 Å)