4QAG

Structure of a dihydroxycoumarin active-site inhibitor in complex with the RNASE H domain of HIV-1 reverse transcriptase

Replaces:  4JE2

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Reverse transcriptase/ribonuclease H	polymer	133	14714.7	2	UniProt (P03366) Pfam (PF00075)	Human immunodeficiency virus type 1 (HIV-1)	Exoribonuclease H, p66 RT
2	C, D, F, G (A, B)	MANGANESE (II) ION	non-polymer		54.9	4	Chemie (MN)
3	E, H (A, B)	(7,8-dihydroxy-2-oxo-2H-chromen-4-yl)acetic acid	non-polymer		236.2	2	Chemie (F95)
4	I, J (A, B)	water	water		18.0	176	Chemie (HOH)

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	29429.3
Non-Polymers*	Number of molecules	6
	Total formula weight	692.1
All*	Total formula weight	30121.4

*Water molecules are not included.