4Q9Z

Human Protein Kinase C Theta in Complex with Compound35 ((1R)-9-(AZETIDIN-3-YLAMINO)-1,8-DIMETHYL-3,5-DIHYDRO[1,2,4]TRIAZINO[3,4-C][1,4]BENZOXAZIN-2(1H)-ONE)

4Q9Z の概要

• エントリーDOI: 10.2210/pdb4q9z/pdb
• 関連するPDBエントリー: 4Q9S
• 分子名称: HUMAN PROTEIN KINASE C THETA, (1R)-9-(azetidin-3-ylamino)-1,8-dimethyl-3,5-dihydro[1,2,4]triazino[3,4-c][1,4]benzoxazin-2(1H)-one, SODIUM ION, ... (4 entities in total)
• 機能のキーワード: pkc theta kinase, kinase catalytic domain, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Cytoplasm: Q04759
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 79818.71

構造登録者

Argiriadi, M.A.,George, D.M. (登録日: 2014-05-02, 公開日: 2014-07-02, 最終更新日: 2015-01-21)

• 主引用文献: George, D.M.,Breinlinger, E.C.,Friedman, M.,Zhang, Y.,Wang, J.,Argiriadi, M.,Bansal-Pakala, P.,Barth, M.,Duignan, D.B.,Honore, P.,Lang, Q.,Mittelstadt, S.,Potin, D.,Rundell, L.,Edmunds, J.J.; Discovery of Selective and Orally Bioavailable Protein Kinase C theta (PKC theta ) Inhibitors from a Fragment Hit.; J.Med.Chem., 58:222-236, 2015; PubMed: 25000588; DOI: 10.1021/jm500669m

実験手法

X-RAY DIFFRACTION (2.6 Å)