4Q9Z
Human Protein Kinase C Theta in Complex with Compound35 ((1R)-9-(AZETIDIN-3-YLAMINO)-1,8-DIMETHYL-3,5-DIHYDRO[1,2,4]TRIAZINO[3,4-C][1,4]BENZOXAZIN-2(1H)-ONE)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | HUMAN PROTEIN KINASE C THETA | polymer | 334 | 39596.5 | 2 | UniProt (Q04759) Pfam (PF00069) Pfam (PF00433) | Homo sapiens (human) | nPKC-theta |
| 2 | C, E (A, B) | (1R)-9-(azetidin-3-ylamino)-1,8-dimethyl-3,5-dihydro[1,2,4]triazino[3,4-c][1,4]benzoxazin-2(1H)-one | non-polymer | 301.3 | 2 | Chemie (PZW) | |||
| 3 | D (A) | SODIUM ION | non-polymer | 23.0 | 1 | Chemie (NA) | |||
| 4 | F, G (A, B) | water | water | 18.0 | 56 | Chemie (HOH) |
Sequence modifications
A, B: 374 - 706 (UniProt: Q04759)
| PDB | External Database | Details |
|---|---|---|
| Glu 381 | Ile 381 | engineered mutation |
| Glu 538 | Thr 538 | engineered mutation |
| His 707 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 79193.0 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 625.7 | |
| All* | Total formula weight | 79818.7 |
