4Q9S

Crystal Structure of human Focal Adhesion Kinase (Fak) bound to Compound1 (3,5-DIHYDRO[1,2,4]TRIAZINO[3,4-C][1,4]BENZOXAZIN-2(1H)-ONE)

Summary for 4Q9S

• Entry DOI: 10.2210/pdb4q9s/pdb
• Related: 4Q9Z
• Descriptor: Focal adhesion kinase 1, 3,5-dihydro[1,2,4]triazino[3,4-c][1,4]benzoxazin-2(1H)-one (3 entities in total)
• Functional Keywords: kinase catalytic domain, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Homo sapiens (human)
• Cellular location: Cell junction, focal adhesion: Q05397
• Total number of polymer chains: 1
• Total formula weight: 32323.34

Authors

Argiriadi, M.A.,George, D.M. (deposition date: 2014-05-01, release date: 2014-07-02, Last modification date: 2024-03-06)

• Primary citation: George, D.M.,Breinlinger, E.C.,Friedman, M.,Zhang, Y.,Wang, J.,Argiriadi, M.,Bansal-Pakala, P.,Barth, M.,Duignan, D.B.,Honore, P.,Lang, Q.,Mittelstadt, S.,Potin, D.,Rundell, L.,Edmunds, J.J.; Discovery of Selective and Orally Bioavailable Protein Kinase C theta (PKC theta ) Inhibitors from a Fragment Hit.; J.Med.Chem., 58:222-236, 2015; PubMed: 25000588; DOI: 10.1021/jm500669m

Experimental method

X-RAY DIFFRACTION (2.07 Å)