4Q9K

P-glycoprotein cocrystallised with QZ-Leu

Summary for 4Q9K

• Entry DOI: 10.2210/pdb4q9k/pdb
• Related: 4Q9H 4Q9I 4Q9J 4Q9L
• Related PRD ID: PRD_001234
• Descriptor: Multidrug resistance protein 1A, (30F)L(30F)L(30F)L Peptide (2 entities in total)
• Functional Keywords: membrane protein, transporter, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Mus musculus (mouse)
• Cellular location: Cell membrane; Multi-pass membrane protein: P21447
• Total number of polymer chains: 2
• Total formula weight: 142721.51

Authors

McGrath, A.P.,Szewczyk, P.,Chang, G. (deposition date: 2014-05-01, release date: 2015-03-04, Last modification date: 2023-11-15)

• Primary citation: Szewczyk, P.,Tao, H.,McGrath, A.P.,Villaluz, M.,Rees, S.D.,Lee, S.C.,Doshi, R.,Urbatsch, I.L.,Zhang, Q.,Chang, G.; Snapshots of ligand entry, malleable binding and induced helical movement in P-glycoprotein.; Acta Crystallogr.,Sect.D, 71:732-741, 2015; PubMed: 25760620; DOI: 10.1107/S1399004715000978

Experimental method

X-RAY DIFFRACTION (3.8 Å)