4Q6A
Staphylococcus aureus V31L, F98Y Mutant Dihydrofolate Reductase Complexed with NADPH
Summary for 4Q6A
Entry DOI | 10.2210/pdb4q6a/pdb |
Related | 4Q67 |
Descriptor | Dihydrofolate reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, GLYCEROL, ... (5 entities in total) |
Functional Keywords | oxidoreductase |
Biological source | Staphylococcus aureus MUF168 |
Total number of polymer chains | 1 |
Total formula weight | 19313.60 |
Authors | Reeve, S.M.,Anderson, A.C. (deposition date: 2014-04-21, release date: 2014-12-31, Last modification date: 2023-09-20) |
Primary citation | Reeve, S.M.,Gainza, P.,Frey, K.M.,Georgiev, I.,Donald, B.R.,Anderson, A.C. Protein design algorithms predict viable resistance to an experimental antifolate. Proc.Natl.Acad.Sci.USA, 112:749-754, 2015 Cited by PubMed: 25552560DOI: 10.1073/pnas.1411548112 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.099 Å) |
Structure validation
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