5WOB
Crystal Structure Analysis of Fab1-Bound Human Insulin Degrading Enzyme (IDE) in Complex with Insulin
Replaces: 4Q5ZSummary for 5WOB
Entry DOI | 10.2210/pdb5wob/pdb |
Descriptor | Insulin-degrading enzyme, Insulin, IDE-bound Fab heavy chain, ... (5 entities in total) |
Functional Keywords | hydrolase, complex |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 32 |
Total formula weight | 1368634.80 |
Authors | McCord, L.A.,Liang, W.G.,Farcasanu, M.,Wang, A.G.,Koide, S.,Tang, W.J. (deposition date: 2017-08-01, release date: 2018-04-18, Last modification date: 2023-10-04) |
Primary citation | Zhang, Z.,Liang, W.G.,Bailey, L.J.,Tan, Y.Z.,Wei, H.,Wang, A.,Farcasanu, M.,Woods, V.A.,McCord, L.A.,Lee, D.,Shang, W.,Deprez-Poulain, R.,Deprez, B.,Liu, D.R.,Koide, A.,Koide, S.,Kossiakoff, A.A.,Li, S.,Carragher, B.,Potter, C.S.,Tang, W.J. Ensemble cryoEM elucidates the mechanism of insulin capture and degradation by human insulin degrading enzyme. Elife, 7:-, 2018 Cited by PubMed: 29596046DOI: 10.7554/eLife.33572 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.95 Å) |
Structure validation
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