4Q4D
Crystal structure of the catalytic domain of human diphosphoinositol pentakisphosphate kinase 2 (PPIP5K2) in complex with AMP-PNP and synthetic 3,5-(PP)2-IP4 (3,5-IP8)
Summary for 4Q4D
Entry DOI | 10.2210/pdb4q4d/pdb |
Related | 4Q4C |
Descriptor | Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, (1R,3S,4S,5R,6S)-2,4,5,6-tetrakis(phosphonooxy)cyclohexane-1,3-diyl bis[trihydrogen (diphosphate)], ... (5 entities in total) |
Functional Keywords | kinase, synthesis, inositol pyrophosphate, enantiomer, transferase |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm, cytosol: O43314 |
Total number of polymer chains | 1 |
Total formula weight | 38968.00 |
Authors | Wang, H.,Shears, S.B. (deposition date: 2014-04-14, release date: 2014-08-06, Last modification date: 2023-09-20) |
Primary citation | Capolicchio, S.,Wang, H.,Thakor, D.T.,Shears, S.B.,Jessen, H.J. Synthesis of Densely Phosphorylated Bis-1,5-Diphospho-myo-Inositol Tetrakisphosphate and its Enantiomer by Bidirectional P-Anhydride Formation. Angew.Chem.Int.Ed.Engl., 53:9508-9511, 2014 Cited by PubMed: 25044992DOI: 10.1002/anie.201404398 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.85 Å) |
Structure validation
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