4Q4D

Crystal structure of the catalytic domain of human diphosphoinositol pentakisphosphate kinase 2 (PPIP5K2) in complex with AMP-PNP and synthetic 3,5-(PP)2-IP4 (3,5-IP8)

4Q4D の概要

• エントリーDOI: 10.2210/pdb4q4d/pdb
• 関連するPDBエントリー: 4Q4C
• 分子名称: Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, (1R,3S,4S,5R,6S)-2,4,5,6-tetrakis(phosphonooxy)cyclohexane-1,3-diyl bis[trihydrogen (diphosphate)], ... (5 entities in total)
• 機能のキーワード: kinase, synthesis, inositol pyrophosphate, enantiomer, transferase
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Cytoplasm, cytosol: O43314
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 38968.00

構造登録者

Wang, H.,Shears, S.B. (登録日: 2014-04-14, 公開日: 2014-08-06, 最終更新日: 2023-09-20)

• 主引用文献: Capolicchio, S.,Wang, H.,Thakor, D.T.,Shears, S.B.,Jessen, H.J.; Synthesis of Densely Phosphorylated Bis-1,5-Diphospho-myo-Inositol Tetrakisphosphate and its Enantiomer by Bidirectional P-Anhydride Formation.; Angew.Chem.Int.Ed.Engl., 53:9508-9511, 2014; PubMed: 25044992; DOI: 10.1002/anie.201404398

実験手法

X-RAY DIFFRACTION (1.85 Å)