4Q21

MOLECULAR SWITCH FOR SIGNAL TRANSDUCTION: STRUCTURAL DIFFERENCES BETWEEN ACTIVE AND INACTIVE FORMS OF PROTOONCOGENIC RAS PROTEINS

4Q21 の概要

• エントリーDOI: 10.2210/pdb4q21/pdb
• 分子名称: C-H-RAS P21 PROTEIN CATALYTIC DOMAIN, MAGNESIUM ION, GUANOSINE-5'-DIPHOSPHATE, ... (4 entities in total)
• 機能のキーワード: oncogene protein
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Cell membrane. Isoform 2: Nucleus: P01112
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 21791.65

構造登録者

Kim, S.-H. (登録日: 1991-09-25, 公開日: 1992-07-15, 最終更新日: 2024-02-28)

• 主引用文献: Milburn, M.V.,Tong, L.,deVos, A.M.,Brunger, A.,Yamaizumi, Z.,Nishimura, S.,Kim, S.H.; Molecular switch for signal transduction: structural differences between active and inactive forms of protooncogenic ras proteins.; Science, 247:939-945, 1990; PubMed: 2406906

実験手法

X-RAY DIFFRACTION (2 Å)