4Q0X

Crystal structure of non-neutralizing antibody in complex with Epitope II of HCV E2

4Q0X の概要

• エントリーDOI: 10.2210/pdb4q0x/pdb
• 関連するPDBエントリー: 4HZL
• 分子名称: mAb 12 heavy chain, mAb 12 light chain, Envelope glycoprotein E2, ... (4 entities in total)
• 機能のキーワード: antibody, anti-hcv e2, hcv e2, immune system-viral protein complex, immune system/viral protein
• 由来する生物種: Mus musculus (mouse); 詳細
• 細胞内の位置: Core protein p21: Host endoplasmic reticulum membrane; Single-pass membrane protein (By similarity). Core protein p19: Virion (By similarity). Envelope glycoprotein E1: Virion membrane; Single-pass type I membrane protein (Potential). Envelope glycoprotein E2: Virion membrane; Single-pass type I membrane protein (Potential). p7: Host endoplasmic reticulum membrane; Multi-pass membrane protein. Protease NS2-3: Host endoplasmic reticulum membrane; Multi-pass membrane protein (Potential). Serine protease NS3: Host endoplasmic reticulum membrane; Peripheral membrane protein (By similarity). Non-structural protein 4A: Host endoplasmic reticulum membrane; Single-pass type I membrane protein (Potential). Non-structural protein 4B: Host endoplasmic reticulum membrane; Multi-pass membrane protein. Non-structural protein 5A: Host endoplasmic reticulum membrane; Peripheral membrane protein. RNA-directed RNA polymerase: Host endoplasmic reticulum membrane; Single-pass type I membrane protein (Potential): P27958
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 50579.36

構造登録者

Deng, L.,Zhang, P. (登録日: 2014-04-02, 公開日: 2014-07-09, 最終更新日: 2014-08-06)

• 主引用文献: Deng, L.,Ma, L.,Virata-Theimer, M.L.,Zhong, L.,Yan, H.,Zhao, Z.,Struble, E.,Feinstone, S.,Alter, H.,Zhang, P.; Discrete conformations of epitope II on the hepatitis C virus E2 protein for antibody-mediated neutralization and nonneutralization.; Proc.Natl.Acad.Sci.USA, 111:10690-10695, 2014; PubMed: 25002515; DOI: 10.1073/pnas.1411317111

実験手法

X-RAY DIFFRACTION (2.9 Å)