4Q0E

Crystal structure of TS-DHFR from Cryptosporidium hominis in complex with NADPH, FdUMP and 2-amino-4-oxo-4,7-dihydro-pyrrolo[2,3-d]pyrimidine-methyl-phenyl-L-glutamic acid.

Summary for 4Q0E

Entry DOI	10.2210/pdb4q0e/pdb
Related	1QZF 2OIP 3DL5 3DL6 3HJ3 4KY8
Descriptor	Bifunctional dihydrofolate reductase-thymidylate synthase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 5-FLUORO-2'-DEOXYURIDINE-5'-MONOPHOSPHATE, ... (5 entities in total)
Functional Keywords	bifunctional enzyme, transferase, oxidoreductase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Cryptosporidium hominis
Total number of polymer chains	5
Total formula weight	310804.40
Authors	Kumar, V.P.,Anderson, K.S. (deposition date: 2014-04-01, release date: 2014-10-15, Last modification date: 2023-09-20)
Primary citation	Kumar, V.P.,Cisneros, J.A.,Frey, K.M.,Castellanos-Gonzalez, A.,Wang, Y.,Gangjee, A.,White, A.C.,Jorgensen, W.L.,Anderson, K.S. Structural studies provide clues for analog design of specific inhibitors of Cryptosporidium hominis thymidylate synthase-dihydrofolate reductase. Bioorg.Med.Chem.Lett., 24:4158-4161, 2014 Cited by PubMed: 25127103 DOI: 10.1016/j.bmcl.2014.07.049 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.78 Å)

Structure validation