4PYL
Humanized rat COMT in complex with sinefungin, Mg2+, and tolcapone
Summary for 4PYL
Entry DOI | 10.2210/pdb4pyl/pdb |
Related | 4P7F 4P7G 4P7K 4PYI 4PYJ 4PYK 4PYM 4PYN 4PYO 4PYQ |
Descriptor | Catechol O-methyltransferase, MAGNESIUM ION, SINEFUNGIN, ... (5 entities in total) |
Functional Keywords | methyltransferase, neurotransmitter degradation, alternative initiation, catecholamine metabolism, cell membrane, membrane, metal-binding, phosphoprotein, signal-anchor, transmembrane anchor, enzyme mechanism, conformational change, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Rattus norvegicus (brown rat,rat,rats) |
Cellular location | Isoform 2: Cytoplasm. Isoform 1: Cell membrane; Single-pass type II membrane protein; Extracellular side: P22734 |
Total number of polymer chains | 1 |
Total formula weight | 25451.33 |
Authors | Ehler, A.,Benz, J.,Schlatter, D.,Rudolph, M.G. (deposition date: 2014-03-27, release date: 2014-06-18, Last modification date: 2024-02-28) |
Primary citation | Ehler, A.,Benz, J.,Schlatter, D.,Rudolph, M.G. Mapping the conformational space accessible to catechol-O-methyltransferase. Acta Crystallogr.,Sect.D, 70:2163-2174, 2014 Cited by PubMed: 25084335DOI: 10.1107/S1399004714012917 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.2 Å) |
Structure validation
Download full validation report