4PY0

Crystal structure of P2Y12 receptor in complex with 2MeSATP

4PY0 の概要

• エントリーDOI: 10.2210/pdb4py0/pdb
• 関連するPDBエントリー: 4NTJ 4PXZ
• 分子名称: P2Y purinoceptor 12, Soluble cytochrome b562, 2-(methylsulfanyl)adenosine 5'-(tetrahydrogen triphosphate), (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, ... (4 entities in total)
• 機能のキーワード: purinergic receptor p2y12, partial agonist-bound, g-protein coupled receptor (gpcr), membrane protein, signaling protein-nucleotide complex, psi-biology, gpcr network, structural genomics, signaling membrane protein, gpcr, platelet activation, membrane
• 由来する生物種: Homo sapiens (human); 詳細
• 細胞内の位置: Cell membrane ; Multi-pass membrane protein : Q9H244
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 54515.23

構造登録者

Zhang, J.,Zhang, K.,Gao, Z.G.,Paoletta, S.,Zhang, D.,Han, G.W.,Li, T.,Ma, L.,Zhang, W.,Muller, C.E.,Yang, H.,Jiang, H.,Cherezov, V.,Katritch, V.,Jacobson, K.A.,Stevens, R.C.,Wu, B.,Zhao, Q.,GPCR Network (GPCR) (登録日: 2014-03-25, 公開日: 2014-04-30, 最終更新日: 2023-11-08)

• 主引用文献: Zhang, J.,Zhang, K.,Gao, Z.G.,Paoletta, S.,Zhang, D.,Han, G.W.,Li, T.,Ma, L.,Zhang, W.,Muller, C.E.,Yang, H.,Jiang, H.,Cherezov, V.,Katritch, V.,Jacobson, K.A.,Stevens, R.C.,Wu, B.,Zhao, Q.; Agonist-bound structure of the human P2Y12 receptor; Nature, 509:119-122, 2014; PubMed: 24784220; DOI: 10.1038/nature13288

実験手法

X-RAY DIFFRACTION (3.1 Å)