4PXZ
Crystal structure of P2Y12 receptor in complex with 2MeSADP
Summary for 4PXZ
Entry DOI | 10.2210/pdb4pxz/pdb |
Related | 4NTJ 4PY0 |
Descriptor | P2Y purinoceptor 12, Soluble cytochrome b562, 2-(methylsulfanyl)adenosine 5'-(trihydrogen diphosphate), CHOLESTEROL, ... (6 entities in total) |
Functional Keywords | purinergic receptor p2y12, agonist-bound, g-protein coupled receptor (gpcr), membrane protein, signaling protein-agonist complex, psi-biology, gpcr network, structural genomics, signaling membrane protein, gpcr, platelet activation, membrane |
Biological source | Homo sapiens (human) More |
Cellular location | Cell membrane ; Multi-pass membrane protein : Q9H244 |
Total number of polymer chains | 1 |
Total formula weight | 55284.57 |
Authors | Zhang, J.,Zhang, K.,Gao, Z.G.,Paoletta, S.,Zhang, D.,Han, G.W.,Li, T.,Ma, L.,Zhang, W.,Muller, C.E.,Yang, H.,Jiang, H.,Cherezov, V.,Katritch, V.,Jacobson, K.A.,Stevens, R.C.,Wu, B.,Zhao, Q.,GPCR Network (GPCR) (deposition date: 2014-03-25, release date: 2014-04-30, Last modification date: 2023-11-08) |
Primary citation | Zhang, J.,Zhang, K.,Gao, Z.G.,Paoletta, S.,Zhang, D.,Han, G.W.,Li, T.,Ma, L.,Zhang, W.,Muller, C.E.,Yang, H.,Jiang, H.,Cherezov, V.,Katritch, V.,Jacobson, K.A.,Stevens, R.C.,Wu, B.,Zhao, Q. Agonist-bound structure of the human P2Y12 receptor Nature, 509:119-122, 2014 Cited by PubMed: 24784220DOI: 10.1038/nature13288 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.5 Å) |
Structure validation
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