4PXF

Crystal structure of the active G-protein-coupled receptor opsin in complex with the finger-loop peptide derived from the full-length arrestin-1

Summary for 4PXF

Entry DOI	10.2210/pdb4pxf/pdb
Related PRD ID	PRD_900006
Descriptor	Rhodopsin, S-arrestin, alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (9 entities in total)
Functional Keywords	retinal protein, photoreceptor, g-protein coupled receptor, phosphoprotein, photoreceptor protein, sensory transduction, transducer, transmembrane, vision, signaling protein, visual arrestin, desensitisation of the visual transduction cascade, binding to acticated and phosphorylated rhodopsin, rhodopsin, opsin
Biological source	Bos taurus (Bovine) More
Cellular location	Membrane; Multi-pass membrane protein: P02699
Total number of polymer chains	2
Total formula weight	42650.43
Authors	Szczepek, M.,Scheerer, P. (deposition date: 2014-03-23, release date: 2014-09-17, Last modification date: 2023-09-20)
Primary citation	Szczepek, M.,Beyriere, F.,Hofmann, K.P.,Elgeti, M.,Kazmin, R.,Rose, A.,Bartl, F.J.,von Stetten, D.,Heck, M.,Sommer, M.E.,Hildebrand, P.W.,Scheerer, P. Crystal structure of a common GPCR-binding interface for G protein and arrestin. Nat Commun, 5:4801-4801, 2014 Cited by PubMed: 25205354 DOI: 10.1038/ncomms5801 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.75 Å)

Structure validation