4PVY

Crystal structure of human FPPS in complex with [({5-[4-(propan-2-yloxy)phenyl]pyridin-3-yl}amino)methanediyl]bis(phosphonic acid)

Summary for 4PVY

Entry DOI	10.2210/pdb4pvy/pdb
Related	4DEM 4NFI 4PVX
Descriptor	Farnesyl pyrophosphate synthase, MAGNESIUM ION, [({5-[4-(propan-2-yloxy)phenyl]pyridin-3-yl}amino)methanediyl]bis(phosphonic acid), ... (5 entities in total)
Functional Keywords	transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Homo sapiens (human)
Cellular location	Cytoplasm: P14324
Total number of polymer chains	1
Total formula weight	43712.26
Authors	Rodionov, D.,Park, J.,De Schutter, J.W.,Tsantrizos, Y.S.,Berghuis, A.M. (deposition date: 2014-03-18, release date: 2015-04-15, Last modification date: 2023-09-20)
Primary citation	Park, J.,Rodionov, D.,De Schutter, J.W.,Lin, Y.S.,Tsantrizos, Y.S.,Berghuis, A.M. Crystallographic and thermodynamic characterization of phenylaminopyridine bisphosphonates binding to human farnesyl pyrophosphate synthase. PLoS ONE, 12:e0186447-e0186447, 2017 Cited by PubMed: 29036218 DOI: 10.1371/journal.pone.0186447 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.05 Å)

Structure validation