4PVX
Crystal structure of human FPPS in complex with [({4-[4-(cyclopropyloxy)phenyl]pyridin-2-yl}amino)methanediyl]bis(phosphonic acid)
Summary for 4PVX
Entry DOI | 10.2210/pdb4pvx/pdb |
Related | 4DEM 4NFI 4PVY |
Descriptor | Farnesyl pyrophosphate synthase, MAGNESIUM ION, [({4-[4-(cyclopropyloxy)phenyl]pyridin-2-yl}amino)methanediyl]bis(phosphonic acid), ... (5 entities in total) |
Functional Keywords | transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm: P14324 |
Total number of polymer chains | 1 |
Total formula weight | 43710.25 |
Authors | Rodionov, D.,Park, J.,Lin, Y.-S.,Tsantrizos, Y.S.,Berghuis, A.M. (deposition date: 2014-03-18, release date: 2015-04-15, Last modification date: 2023-09-20) |
Primary citation | Park, J.,Rodionov, D.,De Schutter, J.W.,Lin, Y.S.,Tsantrizos, Y.S.,Berghuis, A.M. Crystallographic and thermodynamic characterization of phenylaminopyridine bisphosphonates binding to human farnesyl pyrophosphate synthase. PLoS ONE, 12:e0186447-e0186447, 2017 Cited by PubMed: 29036218DOI: 10.1371/journal.pone.0186447 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.18 Å) |
Structure validation
Download full validation report